First, the compatible Operating Systems and Browsers for Mac are Macintosh OS 10.5.7+ (intel-based) and Firefox3.6+ or Safari 4+.

http://www.microsoft.com/getsilverlight/get-started/install/default.aspx

If your system meet the minimal requirements and compatible browser, then please verify that you uninstall and reinstall Silverlight on your Mac follow the steps introuced in the following links:

Removing Silverlight plugins on Mac: http://www.microsoft.com/getsilverlight/get-started/install/removing-silverlight-mac.aspx
Uninstalling previous versions of Silverlight on Mac: http://www.microsoft.com/getsilverlight/get-started/install/uninstall-mac.aspx

Reinstall Silverlight on Mac: http://www.macupdate.com/app/mac/26623/silverlight

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